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Proteome-wide identification of species-specific granzyme A substrates. A, mass spectra of a neo-N terminus derived from tropomyosin 4 (AcD3-98AMKDEEKMEIQEMQLKEAKHIAEEADR124), generated by both hGzmA and mGzmA. B, AcD3-250EGQGLGKHEQGLSTALSVEKTSKR273 from the splicing factor 45, preceded by a Serpinb6b-like tetrapeptide motif (YGFR), was cleaved almost exclusively by mGzmA. AcD3 denotes a trideutero-acetylated α-amino group.
