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Model of the regulation of PFKFB3 by E2. In this schematic, we summarize our model whereby E2 binds and activates ER, translocates to the nucleus, and promotes PFKFB3 mRNA transcription. Translated PFKFB3 produces F26BP which allosterically activates PFK-1 and stimulates glucose uptake and the entire glycolytic pathway.
