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. Author manuscript; available in PMC: 2014 Apr 8.
Published in final edited form as: Arch Neurol. 2012 Apr;69(4):482–489. doi: 10.1001/archneurol.2011.2023

Figure 2.

Figure 2

Aging in male carriers of the fragile X premutation. A, The younger asymptomatic carriers showed greater age-related decline in the fractional anisotropy (FA) of right posterior lateral projections (temporal lobe) of the extreme capsule compared with the controls. B, The younger asymptomatic premutation carriers showed higher tract volume (TV) of the right angular bundle relative to the controls. The fragile X–associated tremor/ataxia syndrome (FXTAS) group showed greater age-related decline in the mean length of the left cingulate bundle (C) and significant elevation and greater age-related elevation in the mean diffusivity (MD) of the posterior body of the corpus callosum (D) compared with the control and asymptomatic groups. Tract-based spatial statistics detected white matter areas with significantly lower FA (E) and higher MD in carriers with FXTAS (F) compared with the controls. Tract-based spatial statistics detected white matter areas with greater age-related decline in FA (G) and greater age-related elevation in MD in carriers with FXTAS (E) compared with the controls. AP indicates asymptomatic premutation carriers; FP, premutation carriers with FXTAS; and NC, normal controls.