Table 2.

MiRNAs downregulated in skin fibrosis

MicroRNA	Associated fibrotic skin diseases	Notable targets	Key skin fibrotic processes	References
Let-7a	Scleroderma	Collagen type I	ECM synthesis	[38]
miRNA-7	Localized scleroderma, keloids	Collagen type I	ECM synthesis	[15]
MiRNA-17- 5p	Hypertrophic scars	TGFβ2R	TGF-β signaling	[51]
MiRNA-18	Hypertrophic scars	Smad4	TGF-β signaling	[51]
MiRNA-20	Hypertrophic scars	TGFβ2R	TGF-β signaling	[51]
miRNA-26a	Scleroderma, keloids	Collagen type I	ECM synthesis	[15]
miRNA-29	Scleroderma	Collagen types I and III, elastin, fibrillin, Wnt/beta catenin, NF-κ, BMAPK	ECM synthesis	[11,19,41,49, 78]
miRNA-129- 5p	Scleroderma, keloids	Collagen type I	ECM synthesis	[15]
miRNA-133a	Scleroderma	Collagen types V and VI	ECM synthesis	[34]
miRNA- 133b	Scleroderma, keloids	Collagen type I	ECM synthesis	[15]
miRNA-140- 5p	Scleroderma	TFGβ2R	TGF-β signaling	[34]
		Collagen type I	ECM synthesis	[34]
miRNA-145	Scleroderma	Smad3	TGF-β signaling	[78]
miRNA-150	Scleroderma	Integrin β3 (indirectly collagen type I	ECM synthesis	[21]
miRNA-196a	Scleroderma, keloids	Collagen types I and III	ECM synthesis	[20,29]
miRNA-200	Keloids	Zeb1, Zeb2, TGF-β2	Epithelial-to- mesenchymal transition	[8,44]
miRNA-203	Keloids	MAPK, TGF-β, and the synthesis of collagen	ECM synthesis	[36]
miRNA-205	Keloids	MAPK, TGF-β, and the synthesis of collagen	ECM synthesis	[36]
miRNA-206	Scleroderma	TFGβ1, TFGβ2	TGF-β signaling	[34]
		Collagen types VI and XIX	ECM synthesis	[34]