TABLE 1.
Characteristics Associated with the Development of Fluoroquinolone-Resistant Escherichia coli Colonization in Hospitalized Patients
| Variable | FQREC negative (n = 322) | FQREC positive (n = 73) | P |
|---|---|---|---|
| Mean age (±SD), years | 61.3 ± 15.1 | 63.2 ± 17.6 | .31 |
| Female sex | 142 (44.1) | 37 (50.7) | .26 |
| Nonwhite race | 124 (38.5) | 32 (43.8) | .05 |
| Surgical service | 72 (22.4) | 12 (16.4) | .02 |
| LOS before the initial sample, days, median (IQR) | 2 (1–5) | 5 (1–12) | <.001 |
| Hospital 2 | 58 (18.0) | 17 (23.3) | <.001 |
| Year of culture | |||
| 2002 (reference) | 97 (30.1) | 32 (43.8) | |
| 2003 | 225 (69.9) | 41 (56.2) | .02 |
| Admitted from nursing home | 16 (5.0) | 5 (6.9) | .02 |
| Transferred from another hospital | 43 (13.4) | 14 (19.2) | .77 |
| UPHS admission in previous 30 days | 99 (30.8) | 27 (37.0) | .98 |
| Urinary catheter | 132 (41.0) | 37 (50.7) | .25 |
| Mechanical ventilation | 45 (14.0) | 18 (24.7) | .63 |
| Central venous catheter | 153 (47.5) | 41 (56.2) | .02 |
| Diarrhea present | 11 (3.4) | 8 (11.0) | .53 |
| Diabetes mellitus | 77 (23.9) | 16 (21.9) | .61 |
| Neutropenia | 9 (3.1) | 0 (0.0) | .13 |
| Hepatic dysfunction | 11 (3.4) | 4 (5.5) | .66 |
| Severe cardiovascular disease | 44 (13.7) | 8 (11.0) | .90 |
| Severe respiratory disease | 40 (12.4) | 7 (9.6) | .36 |
| HIV infection | 6 (1.9) | 2 (2.7) | .02 |
| Malignancy | 147 (45.4) | 18 (24.7) | <.001 |
| Receipt of transplant | 19 (6.1) | 6 (8.7) | .69 |
| Renal insufficiency | 46 (14.3) | 13 (17.8) | .59 |
| Surgical procedure in previous 30 days | 56 (17.4) | 21 (28.8) | .20 |
| Receipt of corticosteroids in previous 30 days | 43 (13.4) | 10 (13.7) | .78 |
note. Data are no. (%) of patients, unless otherwise indicated. FQREC, fluoroquinolone-resistant E. coli; HIV, human immunodeficiency virus; IQR, interquartile range; LOS, length of stay; SD, standard deviation; UPHS, University of Pennsylvania Health System.