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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Gastroenterol. 2013 Oct 7;49(10):1378–1391. doi: 10.1007/s00535-013-0885-z

Fig. 6. Schematic representation of MUC13 regulation and associated cancer pathways influencing MUC13 induced tumorigenesis.

Fig. 6

IL6 treatment induces phosphorylation of P-JAK2 and P-STAT5. Once phosphorylated, P-STAT5 translocates from cytoplasm to nucleus where it binds to the predicted promoter of MUC13 and increases MUC13 production at RNA and protein levels. MUC13 modulates the expression of various oncogenic proteins, resulting in increased tumorigenic features such as cell growth, cell doubling time, cell migration and cell invasion.