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. 2014 Apr 7;55(4):2130–2139. doi: 10.1167/iovs.13-13468

Figure 4.

Figure 4

PKC inhibitors enhance IR-induced gene expression changes in GNAQmt UM cells. The GNAQmt (Mel202, 92.1) and GNAQwt (OCM3) cells were treated with DMSO, BIM (1 μM), or AEB071 (0.5 μM) for 3 hours followed by 0 or 6 Gy of IR. RNA was isolated 18 hours after IR, and mRNA expression was measured for the following genes by quantitative real-time PCR: (A) CDC25A, (B) CCND1, (C) CDKN1A, (D) CDKN1B, (E) TOP2A, (F) TP53BP1. Bars represent mean ± SD from three biological replicates; *P < 0.05 for comparing IR only to PKC inhibitor combined with IR at 6 Gy.