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. Author manuscript; available in PMC: 2014 Apr 8.
Published in final edited form as: J Chem Inf Model. 2012 Jul 31;52(8):2273–2286. doi: 10.1021/ci300072q

Figure 3. Protein – Protein Interactions and Interface Networks (P2IN) versus Protein-Protein Interaction Network (PIN).

Figure 3

(a) A subset of PRISM predictions represented with P2IN and (b) its PIN counterpart. In P2IN the same interface may exist between different protein pairs (CDK6 – CDKN2D; CDK4 – TAF1 interact via same interface) and the same protein pair may interact using different interfaces (CDKN2D and CDK4). Moreover many proteins may compete to bind the same binding on a protein (RAD51, CCNE1 and HDAC1 bind the same site on CDK6). PIN's are not capable of depicting such structural information of protein interactions.