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The predicted hotspots of CDK4 (cyan) and CDK6 (orange) proteins are represented with “Licorice” and the hotspots of CDKN2D are drawn as a (red) surface, using VMD 90. The red, transparent body in the background is also CDKN2D protein. CDK4 and CDK6 have a number of identical hotspots, when their interfaces with CDKN2D are superimposed.
