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AutoDock 91 is used to dock the drugs (Aminopurvalanol, PD-0332991, CHEBI: 792519, CHEBI: 792520 and Fisetin) to candidate off target CDK4. The hotspot (CDK6 residue Ile19) that is closest to the ligands’ binding region on CDK6, is also present on the binding region of CDK4 (residue Ile12).
