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. Author manuscript; available in PMC: 2014 Apr 8.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2012 July-August;1(4):469–478. doi: 10.1002/wdev.53

Figure 1.

Figure 1

Spatial regulation of goosecoid by short enhancers. (A) Wnt and Nodal signaling areas are shaded in red and in green. The overlapping region (right panel) corresponds to Spemann’s organizer where gsc is activated. (B) Upon Wnt signaling activation, siamois and twin are transcribed via β-catenin and Tcf/Lef. Siamois and Twin homeodomain proteins bind to the proximal enhancer of gsc. A Smad2/4 complex is also formed in the distal enhancer of gsc where nodal signaling is active. These complexes interact synergistically and gsc expression becomes spatially defined in the Spemann’s organizer region.