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. Author manuscript; available in PMC: 2014 Dec 5.
Published in final edited form as: Nature. 2013 Nov 6;504(7478):158–162. doi: 10.1038/nature12675

Figure 3. Enriched CD71+ cells compromise neonatal host defence against infection.

Figure 3

a, The proportion of CD71+TER119+ splenocytes and the number of recoverable bacteria (CFU) 48 h after L. monocytogenes (Lm) infection of neonatal mice treated with anti-CD71 antibody or isotype control (rat IgG) antibody. b, The number of recoverable bacteria after L. monocytogenes infection of mice during postnatal development and adult mice. c, The proportion of CD71+TER119+ splenocytes in mice during postnatal development and adult mice. d, Normalized TNF-α production (percentage maximum, % max) by adult CD11b+ responder cells co-cultured with a 1:1 ratio of splenocytes from mice in each age group. e, Representative flow cytometry plots showing the efficiency of immune lineage cell depletion (left), and cumulative composite data for TNF-α production by adult CD11b+ cells co-cultured with purified CD71+ cells from neonatal or phlebotomized adult mice (right). f, Arginase-1 and arginase-2 expression in CD71+ cells from phlebotomized adult (black) or neonatal (red) splenocytes. Each point represents data from an individual mouse, and the data are representative of three independent experiments. Error bars, mean±s.e.m. HK, heat-killed; stim, stimulation.