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. Author manuscript; available in PMC: 2014 Dec 5.
Published in final edited form as: Nature. 2013 Nov 6;504(7478):158–162. doi: 10.1038/nature12675

Extended Data Figure 4. Arginase inhibition overrides the immunosuppressive properties of neonatal cells.

Extended Data Figure 4

TNF-α production by adult CD11b+ responder cells after stimulation with heat-killed (HK) L. monocytogenes (Lm) alone (black), or co-culture with neonatal splenocytes at a 1:1 ratio (blue), or additional supplementation (red) with arginase inhibitors (nor-NOHA or l-NOHA) (top), or 4-aminobenzoic acid hydrazide (a myeloperoxidase inhibitor), 4′-hydroxy-3′-methoxyacetophenone (an NADPH oxidase inhibitor), sodium diethyldithiocarbamate trihydrate (a superoxide dismutase inhibitor), SB-431542 hydrate (a TGF-β receptor inhibitor), anti-TGF-β antibody (clone 1D11), Sn(iv) protoporphyrin IX dichloride (a haem oxidation inhibitor), acetylcysteine (a reactive oxygen species (ROS) scavenger), 1-methyl-d-tryptophan and 1-methyl-l-tryptophan (IDO inhibitors), and an anti-IL-10 receptor antibody (clone 1B1.3A) (bottom). Each point represents data from an individual mouse, and the data are representative of two independent experiments. Error bars, mean±s.e.m.