table 1.

Events were characterized with respect to their peak kinetic parameters (amplitude, 60–80% rise time, area, half-width and 37–80% decay time) and pre-spike foot (PSF) duration, height and area

							PSF parameters
	Events, n	Amplitude, pA	Rise time, ms	Area, fC	Half-width, ms	Decay time, ms	Duration, ms	Height, pA	Area, fC	Events with PSF, %
HAP1+/+	102.2 ± 10.2	26.1 ± 1.6	0.4 ± 0.03	81.2 ± 5.1	2.2 ± 0.1	2.0 ± 0.1	2.3 ± 0.1	12.2 ± 0.4	13.3 ± 0.6	30.3 ± 2.5
HAP1−/−	60.4 ± 7.1*	24.6 ± 1.7	0.4 ± 0.03	75.5 ± 5.6	2.2 ± 0.2	1.9 ± 0.2	3.04 ± 0.1†	11.2 ± 0.4	17.1 ± 0.9†	26.1 ± 3.0

The parameter ‘Events with PSF, %’ indicates the mean percentage of amperometric spikes preceded by a PSF signal. Data are given as mean ± s.e.m. Total numbers of events analysed per genotype for spike parameters are HAP1^+/+ 1792 (29 cells) and HAP1^−/− 1323 (35 cells). Total numbers of events analysed per genotype for PSF parameters are HAP1^+/+ 523 and HAP1^−/− 326.

^*P < 0.01;

^†P < 0.001.