Table 3.
Gene | SNP ID | SNP No. | Geno | African-American
|
Non-Hispanic white
|
Hispanic
|
||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
N | Mean (FEV1/FVC) | P-value | N | Mean (FEV1/FVC) | P-value | N | Mean (FEV1/FVC) | P-value | ||||
CASP10 | rs10166093 | 10 | AA | 77 | 0.77 | 0.0033 | 179 | 0.75 | NS | 85 | 0.81 | NS |
AG | 55 | 0.71 | 18 | 0.74 | 9 | 0.75 | ||||||
GG | 11 | 0.65 | ||||||||||
rs6750157 | 11 | CC | 97 | 0.76 | 0.0009 | 195 | 0.75 | NS | 93 | 0.81 | NS | |
CT | 47 | 0.70 | 1 | 0.76 | 3 | 0.77 | ||||||
TT | 3 | 0.55 | ||||||||||
rs6435068 | 12 | TT | 68 | 0.77 | 0.026 | 176 | 0.76 | NS | 83 | 0.81 | NS | |
CT | 60 | 0.72 | 17 | 0.75 | 7 | 0.78 | ||||||
CC | 15 | 0.69 | ||||||||||
rs13396523 | 14 | TT | 79 | 0.77 | 0.0014 | 180 | 0.75 | NS | 82 | 0.81 | NS | |
CT | 56 | 0.71 | 17 | 0.74 | 9 | 0.75 | ||||||
CC | 11 | 0.65 | ||||||||||
rs6435069* | 15 | AA | 64 | 0.73 | 0.047 | 51 | 0.76 | NS | 13 | 0.80 | NS | |
AG | 63 | 0.73 | 104 | 0.76 | 46 | 0.80 | ||||||
GG | 17 | 0.81 | 41 | 0.73 | 36 | 0.81 | ||||||
rs3851975 | 16 | AA | 71 | 0.76 | NS | 175 | 0.75 | NS | 90 | 0.81 | NS | |
AC | 60 | 0.71 | 18 | 0.74 | 8 | 0.75 | ||||||
CC | 10 | 0.69 | ||||||||||
rs3851976 | 17 | AA | 99 | 0.74 | NS | 181 | 0.75 | NS | 86 | 0.81 | 0.0038 | |
AG | 39 | 0.75 | 15 | 0.74 | 11 | 0.73 | ||||||
GG | 6 | 0.67 | 1 | 0.85 |
Significant for race×gene interaction (P<0.05).
NS, not significant.