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3'-Br-PAT docked at WT 5-HT2C receptor with 4-(3-bromophenyl) moiety oriented toward TMH 6 (pose 1, panel A) or TMH 3 (pose 2, panel B). Similar to PAT (Figure 5), the 4-(3'-bromo)-phenyl moiety participates in apparent π–π interactions with the W6.48 indole moiety, and, the aromatic part of the tetrahydronapthyl system interacts with F6.51; 6.52 is too far from the ligand for direct interactions.
