Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Ligand affinities (Ki ± SEM; nM) of test ligands at WT and point-mutated 5-HT2C GPCRs
| Test Ligand | WT 5-HT2C | W6.48A 5-HT2C | F6.51A 5-HT2C | F6.52A 5-HT2C |
|---|---|---|---|---|
| 5-HT | 7.5 ± 3.5 | 37.2 ± 10.9 | 4036 ± 1339 | 1059 ± 637.8 |
| PAT | 28.5 ± 9.8 | 2042 ± 830.4 | 172.1 ± 47.1 | 70.18 ± 43.1 |
| 3'-Br-PAT | 11.2 ± 6.0 | 1566 ± 182.5 | 372.9 ± 0.0 | 23.1 ± 4.0 |
| CAT | 8.3 ± 2.5 | 460.1 ± 17.1 | 35.1 ± 3.4 | 15.5 ± 8.4 |
