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Models, from X-ray crystal structures, which show the open form of TIM from Trypanosoma brucei brucei (TbbTIM) where the carboxylate side chain of Glu167 is well solvated (Panel A, PDB entry 5TIM); and, the desolvated closed form of TIM liganded to the intermediate analog phosphoglycolohydroxamate (Panel B, PDB entry 2VXN).
