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Models, from X-ray crystal structures, of the active site of unliganded yeast TIM (light blue, PDB entry 1YPI) and yeast TIM complexed with PGA (tan, PDB entry 2YPI). Ligand binding is accompanied by a 2 Å shift in the position of the carboxylate side chain of Glu-165 towards the bound ligand. Reprinted with permission from Ref. 59. Copyright 2013 American Chemical Society.
