. Author manuscript; available in PMC: 2014 Dec 1.

Published in final edited form as: Biomater Sci. 2013 Aug 7;1(12):1250–1259. doi: 10.1039/C3BM60132C

Table 1.

In vivo experimental procedure

Animal Model	Time points (weeks)	Number of animals	Comment
Rat distal femoral defect model	4, 8, 12 and 16	4 rats at each time points (4×4=16 rats) Each rat underwent through a bilateral surgery: both pure and Sr-Mg doped 3DP β-TCP scaffolds were implanted in contralateral femur.	Histology and histomorphometry
Rat distal femoral defect model	16	4 + 4 = 8 rats Each rat underwent through a unilateral surgery: 3DP pure β-TCP scaffolds were implanted in 4 rats and marked as control group, while 3DP Sr-Mg doped β-TCP scaffolds were implanted in other 4 rats and marked as treatment group.	Type I collagen and osteocalcin were measured from blood serum collected at the time of sacrifice after 16-week. Ca²⁺, Sr²⁺ and Mg²⁺ concentration were measured from urine collected at different time points.