Table 2.
Linear regression models for the association between cognitive abilities and longitudinal relaxation time (T1), MTR and hippocampal volume. N = 565.
| g |
Speed |
Memory |
||||
|---|---|---|---|---|---|---|
| Right | Left | Right | Left | Right | Left | |
| Hippocampus volume | ||||||
| Volume | .09 (.023)* | .05 (.151) | .05 (.24) | .01 (.828) | .05 (.164) | .11 (.003) |
| Gender | .01 (.82) | .01 (.928) | .08 (.117) | .08 (.137) | .04 (.345) | .04 (.369) |
| ICV | .04 (.373) | .06 (.233) | .10 (.069) | .11 (.033) | −.02 (.652) | −.04 (.365) |
| Age 11 IQ | .58 (<.001) | .58 (<.001) | .38 (<.001) | .38 (<.001) | .54 (<.001) | .54 (<.001) |
| T1 | ||||||
| T1 | −.13 (<.001) | −.14 (<.001) | −.20 (<.001) | −.18 (<.001) | −.11 (.002) | −.12 (.001) |
| Gender | −.07 (.046) | −.07 (.036) | −.06 (.144) | −.06 (.164) | .01 (.873) | .01 (.988) |
| Age 11 IQ | .58 (<.001) | .58 (<.001) | .39 (<.001) | .39 (<.001) | .54 (<.001) | .54 (<.001) |
| MTR | ||||||
| MTR | .10 (.004) | .11 (.001) | .15 (<.001) | .14 (<.001) | .06 (.105) | .05 (.157) |
| Gender | −.04 (.252) | −.04 (.272) | −.01 (.796) | −.01 (.865) | .03 (.355) | .04 (.332) |
| Age 11 IQ | .57 (<.001) | .57 (<.001) | .38 (<.001) | .38 (<.001) | .54 (<.001) | .54 (<.001) |
| MD | ||||||
| MD | −.11 (.003) | −.13 (<.001) | −.17 (<.001) | −.15 (<.001) | −.10 (.005) | −.12 (.001) |
| Gender | −.06 (.076) | −.06 (.092) | −.03 (.48) | −.01 (.744) | .02 (.617) | .02 (.621) |
| Age 11 IQ | .58 (<.001) | .58 (<.001) | .39 (<.001) | .39 (<.001) | .55 (<.001) | .55 (<.001) |
| FA | ||||||
| FA | .11 (.001) | .10 (.003) | .15 (<.001) | .12 (.003) | .06 (.128) | .06 (.091) |
| Gender | −.05 (.163) | −.05 (.191) | −.00 (.953) | .00 (.957) | .04 (.327) | .04 (.324) |
| Age 11 IQ | .57 (<.001) | .57 (<.001) | .37 (<.001) | .38 (<.001) | .54 (<.001) | .54 (<.001) |
Note. Values are the standardized β (and p value) for the listed measures of hippocampus integrity predicting measures of cognitive ability. Models used the entire sample.
* Represents associations that became non-significant at p < .05 after correction for multiple testing.
Model: cognition = β1*integrity + β2*Gender + β3*Age 11 IQ.
Where integrity represents measures of hippocampus integrity (T1, MTR, FA, MD and hippocampus volume). ICV is included only for hippocampus volume to correct for head size.