Table 3.
Linear regression models for the association between cognitive abilities and combined longitudinal relaxation time (T1), MTR, FA and MD.
| g |
Speed |
Memory |
|||||
|---|---|---|---|---|---|---|---|
| Right | Left | Right | Left | Right | Left | ||
| STEP 1 | Age | −.04 (.416) | −.04 (.421) | −.07 (.141) | −.08 (.109) | −.03 (.714) | −.02 (.671) |
| Gender | −.02 (.65) | −.02 (.642) | −.014 (.747) | .00 (.947) | .05 (.299) | .04 (.362) | |
| T1 | −.12 (.007) | −.13 (.006) | −.18 (<.001) | −.16 (.001) | −.10 (.028) | −.11 (.019) | |
| MTR | .13 (.021) | .12 (.027) | .13 (.018) | .12 (.027) | .08 (.14) | .07 (.18) | |
| MD | .01 (.853) | −.02 (.664) | −.05 (.337) | −.03 (.612) | −.05 (.42) | −.07 (.167) | |
| FA | .13 (.009) | .08 (.115) | .09 (.079) | .06 (.23) | .07 (.19) | .04 (.382) | |
| Total r squared | .07 | .063 | .102 | .08 | .048 | .048 | |
| STEP 2 | Age | −.02 (.58) | −.02 (.612) | −.06 (.182) | −.07 (.148) | .01 (.977) | .00 (.995) |
| Gender | −.07 (.052) | −.07 (.047) | −.05 (.234) | −.03 (.429) | −.01 (.871) | −.01 (.81) | |
| T1 | −.12 (.002) | −.12 (.002) | −.17 (<.001) | −.15 (<.001) | −.10 (.011) | −.11 (.008) | |
| MTR | .07 (.117) | .07 (.123) | .09 (.069) | .09 (.088) | .03 (.553) | .02 (.622) | |
| MD | −.02 (.621) | −.05 (.268) | −.07 (.153) | −.04 (.384) | −.08 (.086) | −.09 (.041)* | |
| FA | .04 (.297) | .01 (.759) | .03 (.487) | .02 (.707) | −.02 (.647) | −.02 (.701) | |
| Age11IQ | .56 (<.001) | .57 (<.001) | .36 (<.001) | .37 (<.001) | .54 (<.001) | .54 (<.001) | |
| Total r squared | .371 | .373 | .228 | .213 | .325 | .328 | |
| MMSE above 27, N = 483 | |||||||
| g |
Speed |
Memory |
|||||
|---|---|---|---|---|---|---|---|
| Right | Left | Right | Left | Right | Left | ||
| STEP 1 | Age | −.04 (.409) | −.05 (.372) | −.07 (.206) | −.08 (.161) | −.03 (.631) | −.04 (.464) |
| Gender | −.08 (.09) | −.09 (.075) | −.07 (.143) | −.06 (.179) | −.02 (.629) | −.02 (.69) | |
| T1 | −.10 (.038)* | −.10 (.055) | −.15 (.003) | −.13 (.008) | −.07 (.139) | −.05 (.383) | |
| MTR | .14 (.021) | .12 (.043)* | .15 (.01) | .14 (.016) | .08 (.198) | .04 (.467) | |
| MD | .01 (.878) | −.06 (.236) | −.05 (.358) | −.10 (.068) | −.05 (.382) | −.10 (.065) | |
| FA | .15 (.004) | .12 (.022) | .12 (.022) | .09 (.08) | .10 (.076) | .10 (.058) | |
| Total r squared | .079 | .079 | .11 | .105 | .044 | .048 | |
| STEP 2 | Age | −.03 (.504) | −.03 (.519) | −.06 (.254) | −.06 (.223) | −.01 (.81) | −.02 (.671) |
| Gender | −.10 (.022) | −.10 (.011) | −.08 (.074) | −.08 (.083) | −.04 (.381) | −.04 (.394) | |
| T1 | −.11 (.011) | −.12 (.006) | −.15 (.001) | −.15 (.002) | −.09 (.053) | −.07 (.117) | |
| MTR | .08 (.101) | .08 (.128) | .12 (.033)* | .11 (.038)* | .03 (.604) | .00 (.949) | |
| MD | −.03 (.569) | −.08 (.087) | −.08 (.173) | −.11 (.036)* | −.09 (.078) | −.12 (.017)* | |
| FA | .06 (.211) | .04 (.382) | .07 (.195) | .04 (.388) | .01 (.925) | .03 (.58) | |
| Age11IQ | .51 (<.001) | .52 (<.001) | .31 (<.001) | .32 (<.001) | .48 (<.001) | .48 (<.001) | |
| Total r squared | .331 | .339 | .205 | .205 | .260 | .265 | |
Note. Values are the standardized β (and p value) for the listed measures of hippocampus integrity predicting measures of cognitive abilities. Models used the entire sample.
* Represents associations that became non-significant at p < .05 after correction for multiple testing.
Model: cognition = β1*Ages + β2*Gender + β3*T1MAP + β4*MTR + β5*MD + β6*FA + β7*Age 11 IQ. Step 1 did not include age 11 IQ but step 2 included age 11 IQ. This stepwise modelling allowed us to compute the variance in cognition exclusively explained by age 11 IQ.