Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Apr 8;9(4):e93248. doi: 10.1371/journal.pone.0093248

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(a) An exemplary cluster with one reliable binding site and a seed match for miR-9. The red rectangle is the binding site, which has 14 mutant tags out of 45 total tags. The miR-9 seed motif is ACCAAAG, which locates 20 bp downstream of the binding site. (b) The positions of seed matches of miR-9 (positions 2–8) within the 5,795 significant clusters. 4 out of 199 seed motifs are more than 100 bp upstream or downstream away from the binding sites, which are ignored. X-axis is the relative position with respect to the binding site within each cluster. (c) The pileup of seed matches of the top 10 miRNAs (positions 2–8) within the 5,795 significant clusters drawn as density curves. 49 out of 1557 seed motifs (all top 10 miRNAs) are more than 100 bp upstream or downstream away from the binding sites, which are ignored. (d) The signal/noise ratio of miRNA seed motif enrichment. The blue bars show enrichment ratios for MiClip and the orange bars show enrichment ratios for the ad hoc method. The numbers on top of these bars show the signal/noise ratio for clusters found by MiClip divided by the signal/noise ratio for clusters found by the ad hoc method.