Table 1. The calculated ^*pK_a values of amino acids in p7 protein.

A. A.	Position	Chain	pKa	A. A.	Position	Chain	pKa
HIS	17	A	6.07	LYS	3	D	10.30
HIS	31	A	5.44	LYS	33	D	9.58
HIS	59	A	5.77	LYS	3	E	10.05
HIS	17	B	5.52	LYS	33	E	9.60
HIS	31	B	5.63	LYS	3	F	10.13
HIS	59	B	5.56	LYS	33	F	9.51
HIS	17	C	6.12	ARG	35	A	11.95
HIS	31	C	5.62	ARG	54	A	12.37
HIS	59	C	5.81	ARG	57	A	12.34
HIS	17	D	5.89	ARG	60	A	12.42
HIS	31	D	5.56	ARG	35	B	12.07
HIS	59	D	5.73	ARG	54	B	12.35
HIS	17	E	6.22	ARG	57	B	12.27
HIS	31	E	5.63	ARG	60	B	12.37
HIS	59	E	5.77	ARG	35	C	12.10
HIS	17	F	5.53	ARG	54	C	12.33
HIS	31	F	5.50	ARG	57	C	12.30
HIS	59	F	5.87	ARG	60	C	12.44
TYR	42	A	9.94	ARG	35	D	12.06
TYR	42	B	10.03	ARG	54	D	12.38
TYR	42	C	10.21	ARG	57	D	12.31
TYR	42	D	10.13	ARG	60	D	12.44
TYR	42	E	10.38	ARG	35	E	12.03
TYR	42	F	10.29	ARG	54	E	12.33
LYS	3	A	10.13	ARG	57	E	12.27
LYS	33	A	9.12	ARG	60	E	12.43
LYS	3	B	10.10	ARG	35	F	11.96
LYS	33	B	9.88	ARG	54	F	12.33
LYS	3	C	10.20	ARG	57	F	12.20
LYS	33	C	10.01	ARG	60	F	12.44
Amantadine		9.00 [28]		Rimantadine		10.40 [28]

*PROPKA3.1 [24]–[27]. (http://propka.ki.ku.dk/pka/2M6X.html).