Table 2. List of differentially expressed proteins in plasma of RA patients with respect to healthy control.
Spot No. | Protein identified | Accession No. | M.W.(Da)/PI calculated | Peptide matched | Biological Functions |
1 | Haptoglobin beta chain | P00738 | 45,205/6.13 | 11 | Cellular iron ion homeostasis, Defence response to bacterium, Intestinal permeability |
2 | Human Serum Albumin | P02768 | 69,366/5.92 | 12 | Regulation of the colloidal osmotic pressure of blood, Bile salts transport, Lipid metabolism |
3 | Serum amyloid protein | P02743 | 26,246/5.97 | 6 | Acute phase inflammation, Transport of cholesterol |
4 | Apolipoprotein A 1 | P02647 | 30,778/5.56 | 11 | Cholesterol transport, Fat efflux from tissue |
5 | Alpha-1 Microglobulin | P02760 | 38,999/5.95 | 9 | Cell adhesion, Heme Catabolism, Regulation of Immune response |
6 | HP alpha 2 chain | P00738 | 16,330/6.1 | 6 | Associated with higher serum iron, Decreased antimicrobial and antioxidant capability, Antigen binding |
7 | HP alpha 2 chain | P00738 | 16,330/6.1 | 12 | Antigen binding, Defence response |
8 | HP alpha 2 chain | P00738 | 16,330/6.1 | 12 | Intestinal permeability, allowing intercelllular tight junction disassembly |
9 | Transthyretin | P02766 | 15,887/5.49 | 9 | Transport, Retinol metabolic process, Phototransduction, extracellulal matrix organization |
M.W. – Molecular Weight, PI - Isoelectric Point.