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. 2014 Apr 8;9(4):e93965. doi: 10.1371/journal.pone.0093965

Figure 5. Paracrine functions of nondiabetic and diabetic CD34+ cells and CM derived from these cells in rat arterioles.

Figure 5

A, Constriction of rat posterior cerebral arterioles with increased intraluminal pressure was lower when nondiabetic cells were present intraluminally compared to constriction without cells (P<0.001, two-way ANOVA). Constriction was unaltered by diabetic cells. B, Contraction to 300 nM phenylephrine was decreased by nondiabetic-CM compared to the control medium (*P<0.04), but diabetic-CM had no effect. Relaxation to 100 nM bradykinin was potentiated by nondiabetic-CM compared to the control medium (**P<0.001) and was not altered in the presence of diabetic-CM. C, Nondiabetic-CM stimulated formation of cGMP and cAMP in the intact arterial segments, and the response produced by diabetic-CM was significantly lower [P<0.0001 (cGMP) and P<0.02 (cAMP), n = 5].