Figure 3. Although Bmpr2^delx4+ causes increased NF-κB activity, this is probably the result of inflammatory cell recruitment (A) Bmpr2^delx4+ causes increased NF-κB activity in the chest.

P = .03 by correlation z-test, p<.01 by multiple ANOVA for genotype effect, Fischer’s LSD shows 14 days different than controls at p<.01, 35 days different than controls at p<.05. Each circle corresponds to an individual animal, normalized to control measurements. (B) Bmpr2^delx4+ does not cause increased NF-κB activity in the abdomen by either correlation z-test or multiple ANOVA. (C) NF-κB is increased ∼5x in spleen from Bmpr2^delx4+ transgenic mice (p<.05 by ANOVA), but not significantly in other organs (luciferase activity is normalized to that in controls, n = 4–8 per organ per group).