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. 2014 Apr 8;9(4):e94175. doi: 10.1371/journal.pone.0094175

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© 2014 Wilson et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Brn3a-labeled flat-mounted retinas from axotomized eyes demonstrate higher RGC densities following treatment with AAV.iASPP (A) than with AAV.GFP (B) at one week post-injury. Scale bars: 100 μm. Quantitative analysis of RGC survival following axotomy and intraocular injection of AAV.iASPP (black) or control AAV.GFP (grey) (ANOVA, *** = p<0.001) at one and two weeks post-injury (C). The density of RGCs in intact, uninjured Sprague-Dawley rat retinas is shown as reference (open bar). Data are expressed as the mean ± S.E.M.