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. 2014 Apr 8;9(4):e94702. doi: 10.1371/journal.pone.0094702

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© 2014 Lin et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A and B) Adoptive transfer of iTreg cells generated from CD4⁺CD25⁺ cells. (C and D) Adoptive transfer of iTreg cells generated from CD4⁺CD25⁻ cells. Both kinds of transferred cells efficiently abrogated the CpG-induced increase of embryo-resorption and preterm birth in NOD mice. No change of embryo-resorption or preterm birth was observed in WT mice treated with CpG or cell transfer. Ten female mice were used in each group.