Figure 2. A dual role for Tip60 in adipogenesis. Tip60 is protected from proteasomal degradation by the deubiquitinase USP7 in early adipogenesis and plays a role in regulating genes involved in MCE, probably as part of the Tip60-containing NuA4 complex. Whether Tip60/NuA4 is recruited to cell cycle genes (e.g., Cdc20, Aurka) through a specific transcription factor (TF) during MCE is currently unknown. During late adipogenesis Tip60 is recruited to lipid handling genes (e.g., FABP4, perilipin) by PPARγ-RXR.