Figure 1. The pseudohypoxia-switching hub: A unifying link between gerometabolites and oncometabolites. Transition from oxidative metabolism into Warburg-like aerobic glycolysis sets a cell metabotype commonly shared by aging and cancer. The intriguing convergence of gerometabolites and oncometabolites on Myc, the so-called “oncogene from hell”, provides not only evidence for a key molecular “funnel factor” linking metabolism with aging–cancer signatures, but also provocatively implicates Myc as a distinctive mechanistic target to decelerate aging and postpone age-related diseases such as cancer without the emergence of resistance phenomena.