Figure 2. Gerometabolites and oncometabolites could control HIFα homeostasis by its rate of translation (left) and degradation (right). Proteins colored in green represent HIFα downregulators (e.g., gerosuppressors) whereas those in red represent HIFα inducers (e.g., gerogenes, oncometabolites). While it is obvious that the antifungal antibiotic rapamycin, the polyphenol resveratrol, and the biguanide metformin already belong to the family of gerosuppressor-targeting drugs, other SIRT1 activators such as NMN and oncometabolite inhibitors (e.g., BPTES, AGI-5198) should be viewed as drug candidates that could reverse or postpone the pseudohypoxia-switching hub driving aging and cancer.