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Cytotoxic and Antitumor Activity of Taxol (1)
|
Cytotoxic Activity
| ||
|---|---|---|
| KB (human carcinoma of the nasopharynx): | ||
| ED50 =3.5 × 10−5 μg/mL | ||
| (ED50 = conc. required for 50% inhibition of growth) | ||
| Antitumor Activity
| ||
| System Tested | Administration | Activity (% T/C) |
| i.p P388 Leukemia | i.p. | + (164) |
| i.p. B16 Melanoma | i.p. | ++ (283) |
| i.p. L1210 Leukemia | i.p. | + (139) |
| S.R.C* CX-1 Colon Xenograft | s.c. | ++ (3) |
| S.R.C. LX- Lung Xenograft | s.c. | + (8) |
| S.R.C. MX-1 Mammary Xenograft | s.c. | ++ (−77) |
Sub-renal capsule
