Skip to main content
. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Neurochem. 2013 Dec 13;129(2):315–327. doi: 10.1111/jnc.12616

Figure 4. Enhanced control of NAc DA release by α6* nAChRs in α6L9’S mice.

Figure 4

A) Peak oxidative current vs. time is shown for DA release responses from nonTg NAc slices before and after bath application of αCtxMII (100 nM). Responses following both 1P and 4P (30 Hz) stimulations were recorded. The number of responses was: 1P control, n=4; 1P αCtxMII, n=4; 4P control, n=4; 4P αCtxMII, n=4.

B) Peak oxidative current vs. time is shown for DA release responses from α6L9’S NAc slices before and after bath application of αCtxMII (100 nM). Responses following both 1P and 4P (30 Hz) stimulations were recorded. The number of responses was: 1P control, n=4; 1P αCtxMII, n=4; 4P control, n=4; 4P αCtxMII, n=4.

C) Relative DA signal values are shown for the 4 conditions X 2 genotypes shown in A) and B). The area under the peak oxidative current vs. time curve was derived for all conditions in A) and B), and data from nonTg and α6L9’S NAc were normalized to their respective 1P pre-drug control values. ***p<0.001, **p<0.01, *p<0.05

D) Peak oxidative current vs. time is shown for DA release responses from nonTg NAc slices before and after bath application of mecamylamine (10 μM). Responses following both 1P and 4P (30 Hz) stimulations were recorded. The number of responses was: 1P control, n=6; 1P αCtxMII, n=6; 4P control, n=6; 4P αCtxMII, n=6.

E) Peak oxidative current vs. time is shown for DA release responses from α6L9’S NAc slices before and after bath application of mecamylamine (10 μM). Responses following both 1P and 4P (30 Hz) stimulations were recorded. The number of responses was: 1P control, n=4; 1P αCtxMII, n=4; 4P control, n=4; 4P αCtxMII, n=4.

F) Relative DA signal values are shown for the 4 conditions X 2 genotypes shown in D) and E). The area under the peak oxidative current vs. time curve was derived for all conditions in D) and E), and data from nonTg and α6L9’S NAc were normalized to their respective 1P pre-drug control values. ***p<0.001, **p<0.01, *p<0.05