Table 3.
The relationship between clinicopathological features of tumor and the expression of MMP-2 and TIMP-2
| Variable analyzed | MMP-2 | TIMP-2 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Colorectal cancer cells | Inflammatory infiltrate cells | Normal colorectal tissue | Colorectal cancer cells | Inflammatory infiltrate cells | Normal colorectal tissue | |||||||||||||
| Negative | Positive | p | Negative | Positive | p | Negative | Positive | p | Negative | Positive | p | Negative | Positive | p | Negative | Positive | p | |
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||||||
| Colorectal cancer | 55 (76.4) | 17 (23.6) | 36 (50.0) | 36 (50.0) | 71 (98.6) | 1 (1.4) | 9 (12.5) | 63 (87.5) | 18 (25.0) | 54 (75.0) | 61 (84.7) | 11 (15.3) | ||||||
| Tumor stage (Duke’s classification) | ||||||||||||||||||
| A + B1 + B2 | 19 (67.9) | 9 (32.1) | 0.181 | 11 (39.3) | 17 (60.7) | 0.070 | 28 (100.0) | 0 (0.0) | 0.292 | 4 (14.3) | 24 (85.7) | 0.820 | 6 (21.4) | 22 (78.6) | 0.076 | 26 (92.9) | 2 (7.1) | 0.083 |
| C1 + C2 | 17 (73.9) | 6 (26.1) | 10 (43.5) | 13 (56.5) | 23 (100.0) | 0 (0.0) | 2 (8.7) | 21 (91.3) | 3 (13.0) | 20 (87.0) | 16 (69.6) | 7 (30.4) | ||||||
| D | 19 (90.5) | 2 (9.5) | 15 (71.4) | 6 (28.6) | 20 (95.2) | 1 (4.8) | 3 (14.3) | 18 (85.7) | 9 (42.9) | 12 (57.1) | 19 (90.5) | 2 (9.5) | ||||||
| Tumor size (T factor) | ||||||||||||||||||
| T1 + T2 | 4 (80.0) | 1 (20.0) | 0.336 | 1 (20.0) | 4 (80.0) | 0.496 | 5 (100.0) | 0 (0.0) | 1.000 | 1 (20.0) | 4 (80.0) | 0.215 | 0 (0.0) | 5 (100.0) | 0.003* | 4 (80.0) | 1 (20.0) | 0.863 |
| T3 | 43 (79.6) | 11 (20.4) | 28 (51.9) | 26 (48.1) | 53 (98.1) | 1 (1.9) | 5 (9.3) | 49 (90.7) | 10 (18.5) | 44 (81.5) | 46 (85.2) | 8 (14.8) | ||||||
| T4 | 8 (61.5) | 5 (38.5) | 7 (53.8) | 6 (46.2) | 13 (100.0) | 0 (0.0) | 3 (23.1) | 10 (76.9) | 8 (61.5) | 5 (38.5) | 11 (84.6) | 2 (15.4) | ||||||
| Nodal involvement (N factor) | ||||||||||||||||||
| N0 | 20 (66.7) | 10 (33.3) | 0.155 | 12 (40.0) | 18 (60.0) | 0.112 | 30 (100.0) | 0 (0.0) | 0.125 | 4 (13.3) | 26 (86.7) | 0.181 | 6 (20.0) | 24 (80.0) | 0.007* | 27 (90.0) | 3 (10.0) | 0.107 |
| N1 | 17 (73.9) | 6 (26.1) | 10 (43.5) | 13 (56.5) | 23 (100.0) | 0 (0.0) | 1 (4.3) | 22 (95.7) | 2 (8.7) | 21 (91.3) | 16 (69.6) | 7 (30.4) | ||||||
| N2 | 9 (100.0) | 0 (0.0) | 6 (66.7) | 3 (33.3) | 8 (88.9) | 1 (11.1) | 3 (33.3) | 6 (66.7) | 4 (44.4) | 5 (55.6) | 9 (100.0) | 0 (0.0) | ||||||
| N3 | 9 (90.0) | 1 (10.0) | 8 (80.0) | 2 (20.0) | 10 (100.0) | 0 (0.0) | 1 (10.0) | 9 (90.0) | 6 (60.0) | 4 (40.0) | 9 (90.0) | 1 (10.0) | ||||||
| Distant metastases (M factor) | ||||||||||||||||||
| M0 | 36 (70.6) | 15 (29.4) | 0.125 | 21 (41.2) | 30 (58.8) | 0.037* | 51 (100.0) | 0 (0.0) | 0.292 | 6 (11.8) | 45 (88.2) | 0.714 | 9 (17.6) | 42 (82.4) | 0.036* | 42 (82.4) | 9 (17.6) | 0.491 |
| M1 | 19 (90.5) | 2 (9.5) | 15 (71.4) | 6 (28.6) | 20 (95.2) | 1 (4.8) | 3 (14.3) | 18 (85.7) | 9 (42.9) | 12 (57.1) | 19 (90.5) | 2 (9.5) | ||||||
*p < 0.005, statistically significant