Table 5.
Correlations between serum levels and tissue expression of MMP-2 and TIMP-2 in colorectal cancer patients
| Variable analyzed | Serum TIMP-2 | Tissue MMP-2 in cancer cells | Tissue MMP-2 in inflammatory cells | Tissue MMP-2 in normal cells | Tissue TIMP-2 in cancer cells | Tissue TIMP-2 in inflammatory cells | Tissue TIMP-2 in normal cells |
|---|---|---|---|---|---|---|---|
| r (p) | r (p) | r (p) | r (p) | r (p) | r (p) | r (p) | |
| Serum MMP-2 | 0.51 (<0.001*) | 0.22 (0.064) | 0.14 (0.239) | 0.07 (0.551) | 0.09 (0.458) | 0.29 (0.012*) | 0.24 (0.039*) |
| Serum TIMP-2 | 0.16 (0.187) | 0.02 (0.844) | −0.15 (0.196) | −0.03 (0.802) | 0.17 (0.153) | 0.17 (0.163) | |
| Tissue MMP-2 in cancer cells | 0.32 (0.006*) | −0.07 (0.585) | 0.06 (0.625) | 0.11 (0.347) | 0.12 (0.304) | ||
| Tissue MMP-2 in inflammatory cells | 0.09 (0.442) | 0.24 (0.040*) | 0.35 (0.003*) | 0.23 (0.050*) | |||
| Tissue MMP-2 in normal cells | −0.11 (0.365) | −0.02 (0.899) | −0.05 (0.674) | ||||
| Tissue TIMP-2 in cancer cells | 0.47 (<0.001*) | 0.13 (0.264) | |||||
| Tissue TIMP-2 in inflammatory cells | 0.34 (0.004*) |
r indicates correlation coefficient
*p < 0.005, statistically significant