Table 6.
Univariate Cox analysis of regression
| Variable tested | p | HR |
|---|---|---|
| Age | 0.997 | 1.000 |
| Tumor stage (Duke’s classification) | 0.086 | |
| C1 + C2 vs A + B1 + B2 | 0.970 | 0.000 |
| D vs A + B1 + B2 | 0.027* | 11.259 |
| Tumor size (T factor) | 0.230 | |
| T3 vs T2 | 0.962 | 9,271.216 |
| T4 vs T2 | 0.956 | 34,627.135 |
| Nodal involvement (N factor) | 0.127 | |
| N1 vs N0 | 0.967 | 0.000 |
| N2 vs N0 | 0.018* | 14.347 |
| N3 vs N0 | 0.054 | 11.127 |
| Distant metastases (M factor) | 0.006* | 20.674 |
| Resectability of tumor | 0.002* | 0.073 |
| Serum MMP-2 | 0.968 | 1.000 |
| Serum TIMP-2 | 0.662 | 1.009 |
| Tissue MMP-2 in cancer cells | 0.498 | 0.480 |
| Tissue MMP-2 in inflammatory cells | 0.331 | 2.281 |
| Tissue MMP-2 in normal cells | 0.030* | 11.361 |
| Tissue TIMP-2 in cancer cells | 0.551 | 24.715 |
| Tissue TIMP-2 in inflammatory cells | 0.141 | 0.299 |
| Tissue TIMP-2 in normal cells | 0.445 | 0.035 |
*p < 0.005, statistically significant