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(a–c) Plasma glucose, (d–f) C-peptide and (g–i) insulin concentrations, and (j–l) ISR per plasma glucose values in Study 1. Black circles, baseline; white circles, Week 26. Values are mean ± SEM for placebo (a, d, g, j), canagliflozin 100 mg (b, e, h, k) and canagliflozin 300 mg (c, f, i, l)
