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. 2013 Nov 25;5(Suppl 1):S8. doi: 10.1186/alzrt223

Figure 4.

Figure 4

Dynamic biomarkers of Alzheimer's disease pathological cascade. The dynamic biomarkers of Alzheimer's disease pathological cascade, as proposed by Jack and collaborators. This model predicts a preclinical and mild cognitive impairment (MCI) stage of Alzheimer's disease (AD) characterized by predominance of amyloid pathology and a dementia phase characterized by amyloid pathology, neurodegenerative changes and subclinical cognitive impairment. Adapted from [4].