Table 3.

The risk of fast cognitive decline in all dementia cases and in AD cases: the crude and adjusted odds ratios (ORs) and 95% confidence intervals (CI) associated with each 5 pg/ml increase in the various plasma amyloid-β peptide levels. The adjusting factors were gender, age, educational level, center, alcohol consumption, hypertension, IADL, depression, cognitive score at baseline and a history of vascular disease.

	All	dementia		AD
	Adjusted OR	95%CI	p	Adjusted OR	95%CI	p
Isaac Set Test a
Aβ40	0.97	0.92–1.03	0.32	1.02	0.92–1.13	0.76
Aβ42	0.70	0.51–0.96	0.03	0.35	0.15–0.81	0.01
Aβn-40	0.96	0.92–1.01	0.11	0.96	0.90–1.03	0.23
Aβn-42	0.82	0.56–1.20	0.31	0.29	0.11–0.75	0.01
Aβ42/Aβ40	0.36	0.08–1.54	0.17	0.002	0.001–0.18	0.008
Aβn-42/Aβn-40	1.43	0.24–8.53	0.70	0.02	0.001–1.01	0.05
Benton Visual Retention Test b
Aβ40	0.95	0.90–1.01	0.09	0.94	0.85–1.05	0.27
Aβ42	0.72	0.54–0.97	0.03	0.76	0.47–1.21	0.25
Aβn-40	0.99	0.95–1.04	0.68	1.02	0.95–1.10	0.59
Aβn-42	0.84	0.58–1.21	0.35	0.95	0.53–1.71	0.86
Aβ42/Aβ40	0.48	0.12–1.98	0.31	0.57	0.07–4.42	0.59
Aβn-42/Aβn-40	0.46	0.06–3.56	0.46	0.33	0.01–11.49	0.54
MMSE c
Aβ40	1.01	0.97–1.06	0.51	1.03	0.97–1.10	0.36
Aβ42	1.06	0.83–1.34	0.66	1.27	0.89–1.81	0.18
Aβn-40	1.01	0.97–1.05	0.51	1.02	0.96–1.07	0.56
Aβn-42	1.04	0.77–1.40	0.81	1.23	0.80–1.88	0.34
Aβ42/Aβ40	1.11	0.35–3.53	0.86	0.96	0.19–4.96	0.96
Aβn-42/Aβn-40	0.64	0.13–3.13	0.58	0.95	0.10–9.15	0.97

^a111 all dementia cases, including 28 fast decliners; 76 AD cases, including 14 fast decliners.

^b108 all dementia cases, including 27 fast decliners; 73 AD cases, including 12 fast decliners.

^c111 all dementia cases, including 29 fast decliners; 75 AD cases, including 15 fast decliners.