Table 3.

Analysis Results of Variations Identified in Resequencing within the Noncoding Region of BLK

Genomic Location	Nucleotide Change	dbSNP	Associated Allele	Case, Control Ratio Counts (191, 96)	OR (95% CI)	p Value	r2(with rs13277113)
11,349,576	C>A	rs2251056	A	321:61, 150:42	1.47 (0.95–2.28)	0.0819	0.066
11,350,515	C>T	rs76610494	T	8:374, 1:191	4.10 (0.51–32.92)	0.1522	0.006
11,350,678	T>C	rs2736344	C	329:53, 149:43	1.79 (1.15–2.80)	0.0098	0.072
11,350,721	C>G	rs9694294	G	323:59, 149:43	1.58 (1.02–2.45)	0.0398	0.078
11,350,899	T>C	rs1382567	T	199:183, 93:99	1.16 (0.82–1.64)	0.4083	0.335
11,351,019	G>A	rs4840568	A	125:257, 41:151	1.79 (1.29–2.69)	0.0046	0.852
11,351,220	A>C	rs1382568a	C	121:261, 38:154	1.88 (1.24–2.85)	0.0027	0.889
11,351,220	A>G	rs1382568a	A	200:182, 94:98	1.15 (0.81–1.62)	0.4423	0.331
11,351,912	C>T	rs922483	T	137:245, 43:149	1.94 (1.30–2.89)	0.001	0.741
11,352,056	A>G	rs2250788	G	320:62, 148:44	1.53 (0.99–2.37)	0.0514	0.059
11,366,671	C>T	rs115856097	C	274:108, 128:64	1.27 (0.87–1.84)	0.2117	0.037
11,367,037	G>C	rs4629826	G	358:24, 176:16	1.36 (0.70–2.62)	0.3626	0.018
11,367,042	C>T	rs76154097	T	55:327, 23:169	1.24 (0.73–2.08)	0.4249	0.038
11,367,092	T>C	rs2409782	C	91:291, 45:147	1.02 (0.68–1.54)	0.9186	0.001
11,415,571	A>G	rs4841557	A	158:222, 63:129	1.46 (1.01–2.10)	0.042	0.187
11,415,596	C>T	rs4841558	C	157:223, 63:129	1.44 (1.00–2.08)	0.0484	0.181
11,418,385	G>A	rs1042695	A	145:237, 59:133	1.38 (0.95–2.00)	0.0878	0.179
11,418,765	G>A	rs368588162	A	335:45, 157:35	1.66 (1.03–2.68)	0.0375	0.019
11,418,766	G>A	rs62490888	G	340:42, 157:35	1.81 (1.11–2.94)	0.0164	0.015
11,418,772	C>T	rs4841561	T	146:234, 59:133	1.41 (0.97–2.04)	0.07	0.177
11,421,383	C>T	rs10097015	T	160:222, 68:122	1.29 (0.90–1.85)	0.1608	0.161
11,421,793	C>T	rs1042689	T	144:238, 62:130	1.27 (0.88–1.83)	0.2028	0.161
11,422,045	G>A	rs1042701	G	213:169, 98:94	1.21 (0.86–1.71)	0.2845	0.2
11,422,130	T>C	rs7843987	T	212:170, 100:92	1.15 (0.81–1.62)	0.4385	0.219

The two SNPs shown in italics (rs1382568^∗ and rs922483) showed association with the loci identified from the GWAS (rs13277113, OR 1.39, p = 1 × 10⁻¹⁰, ref.1) with r² > 0.5; ^ars1382568 is a tri-allelic SNP (A/C/G); the C allele was identified as a risk allele.