Table 1.
Descriptive Characteristics of Participating Studies
| Covariate |
Discovery |
Replication |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Multicenter, US |
European Studies |
Cincinnati, US |
Cincinnati, US |
|||||||||
|
GOCHA |
HM-ICH + VVH-ICH |
JUHSS |
LSR |
GERFHS I & II |
ERICH/GERFHS III/CCC-GCC |
|||||||
| Case Cohort | Control Cohort | Case Cohort | Control Cohort | Case Cohort | Control Cohort | Case Cohort | Control Cohort | Case Cohort | Control Cohort | Case Cohort | Control Cohort | |
| Subjects, n | 298 | 457 | 212 | 169 | 122 | 163 | 116 | 153 | 797 | 539 | 1,681 | 2,261 |
| Age, mean (SD) | 74 (10) | 72 (8) | 74 (11) | 71 (9) | 67 (12) | 65 (13) | 75 (10) | 75 (10) | 67 (15) | 66 (15) | 62 (15) | 43a (26) |
| Female, n (%) | 134 (45) | 231 (51) | 103 (49) | 77 (46) | 69 (57) | 93 (57) | 49 (42) | 69 (45) | 383 (48) | 243 (45) | 701 (42) | 1,113 (49) |
| Hypertension, n (%) | 217 (73) | 280 (61) | 126 (60) | 99 (64) | 96 (81) | 74 (45) | 76 (67) | 65 (43) | 494 (62) | 280 (52) | 1,009 (60) | 738b (51) |
| Lobar ICH, n (%) | 184 (58) | – | 88 (40) | – | 51 (39) | – | 36 (28) | – | 327 (41) | – | 484 (29) | – |
| Nonlobar ICH, n (%) | 132 (42) | – | 133 (60) | – | 80 (61) | – | 94 (72) | – | 470 (59) | – | 1,197 (71) | – |
Abbreviations are as follows: ICH, intracerebral hemorrhage; GOCHA, Genetics of Cerebral Hemorrhage on Anticoagulation Study; HM-ICH, Hospital del Mar Intracerebral Hemorrhage Study; VVH-ICH, Vall d’Hebron Hospital ICH Study; JUHSS, Jagiellonian University Hemorrhagic Stroke Study; LSR, Lund Stroke Register; GERFHS, Genetic and Environmental Risk Factors for Hemorrhagic Stroke Study; ERICH, Ethnic/Racial Variations of Intracerebral Hemorrhage Study; CCC-GCC, Cincinnati Control Cohort - Genomic Control Cohort.
a
Includes the 819 GCC pediatric control subjects with ages ≤18.
b
Excludes the 819 GCC pediatric control subjects with no hypertension history.