Table 2.
Loci with p < 1 × 10−6 in at least One Subtype of Intracerebral Hemorrhage
|
SNP Characteristics |
Meta-analysis Discovery Phase |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr | Position | Locus | Major/Minor Allele | Tested Allelea | MAF | Type | Gene Landmarks | Trait | OR | p | Q | I |
| rs11179580 | 12 | 73586579 | 12q21.1 | C/T | C | 0.24 | intergenic | TRHDE | all ICH | 1.36 | 7.1 × 10−7 | 0.07 | 61% |
| lobar ICH | 1.56 | 7.0 × 10−8 | 0.43 | 0% | |||||||||
| nonlobar ICH | 1.25 | 0.002 | 0.03 | 72% | |||||||||
| rs2984613 | 1 | 156197380 | 1q22 | C/T | C | 0.32 | intronic | PMF1 SLC25A44 | all ICH | 1.21 | 6.0 × 10−4 | 0.15 | 48% |
| lobar ICH | 0.97 | 0.62 | 0.7 | 1% | |||||||||
| nonlobar ICH | 1.44 | 1.6 × 10−8 | 0.05 | 66% | |||||||||
Abbreviations are as follows: Chr, chromosome; MAF, minor allele frequency; OR, odds ratio; ICH, intracerebral hemorrhage.
a
Showing effect estimates when testing the major allele to depict genetic variation associated with increased risk of ICH.