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. 2014 Apr 3;94(4):533–546. doi: 10.1016/j.ajhg.2014.03.001

Figure 5.

Figure 5

Immunohistochemistry in CNS after Treatment with Lonaprisan in PMD Mice

(A) Immunohistochemistry showing OLIG-2-, MAC-3-, GFAP-, and CD3-positive cells in wild-type and placebo- and Lonaprisan-treated PMD mice.

(B–E) Lonaprisan therapy reduced oligodendrocyte loss (B), microgliosis (C), astrogliosis (D), and lymphocyte infiltration (E).

(F–H) Further, cells positive for c-MYC, Ki67, and BAX were reduced after Lonaprisan therapy, indicating changes in cell cycle regulation resulting in reduced proliferation and apoptosis in PMD mice.

Scale bars represent 10 μm. CST indicates corticospinal tract, CC indicates corpus callosum, ns indicates not significant, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, shown mean ± SEM.