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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2014 Mar 9;21(4):405–412. doi: 10.1038/nsmb.2786

Figure 5. Regulation of repair pathway choice by Sae2 and RPA.

Figure 5

Sae2 is required for resection initiation and prevention of NHEJ repair in S and G2 phases of the cell cycle. End resection creates ssDNA, the substrate for HR and MMEJ. RPA bound to ssDNA inhibits MMEJ between MH internal to the break ends and promotes HR. When RPA binding to ssDNA is perturbed (RPA*) annealing between MH is increased and the efficiency of HR is reduced.