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. 2014 Jan 13;6(1):79–111. doi: 10.3390/cancers6010079

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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p16^Ink4a expression is down regulated in HCC through hypermethylation of CpG islands as a result of increased expression of DNA methyltransferase DNMT1 and DNMT3A associated with hepatitis B virus expression or due to other mechanisms.