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Experimental design. Sham surgery or CAL were performed in rats one week after experimental diabetes (blood glucose: >15 mM) had been induced by streptozotocin. Experimental groups: Sham: hearts subjected to sham surgery; HF: hearts subjected to CAL; Sham+Als: hearts subjected to sham surgery and were treated with aliskiren (Als); CAL+Als: hearts subjected to CAL and were treated with Als.
