Table 1.
Conservation of polyadenylation factors between yeast and mammals.
| Mammalian factor name |
Synonyms | Yeast homologue |
Function | Motifs |
|---|---|---|---|---|
| CPSF | ||||
| CPSF160 | CPSF1 | CFT1/YHH1 | RNA-binding (AAUAAA) | SFT1, CPSF_A |
| Wdr33 | WDC146 | PFS2 | WD40 repeat | |
| Symplekin | PTA1 | Scaffolding | ||
| CPSF100 | CPSF2 | CFT2/YDH1 | b-CASP | |
| CPSF73 | CPSF3 | BRR5/YSH1 | Endonuclease | b-CASP |
| hFip1 | FIP1L1 | FIP1 | RNA-binding | |
| CPSF30 | CPSF4 | YTH1 | RNA-binding | Zinc Finger |
| CstF | ||||
| CstF77 | CSTF3 | RNA14 | Dimerization | HAT repeat |
| CstF64 | CSTF2 | RNA15 | RNA-binding (DSE) | RRM |
| CstF64 t | CSTF2T | PTI1? | RNA-binding (DSE) | RRM |
| CstF50 | CSTF1 | WD40 repeat | ||
| CF Im | ||||
| CF Im 68 | CPSF6 | RNA-binding | RRM | |
| CF Im 59 | CPSF7 | RNA-binding | RRM | |
| CF Im 25 | CPSF5 | Dimerization | Nudix | |
| CF IIm | ||||
| hPcf11 | PCF11 | CID | ||
| hClp1 | HEAB | CLP1 | RNA kinase | GTPase |
| Other factors | ||||
| PAP | PAPOLA | PAP1 | Poly(A) Polymerase | RNA-binding, NTP |
| Neo-PAP | PAPOLG | Poly(A) Polymerase | RNA-binding, NTP | |
| Star-PAP | TUT1 | CID1 (S. pombe) | Poly(A) Polymerase | RNA-binding, NTP, RS |
| PABPN1 | Poly(A) tail length control | RRM | ||
| PABPC1 | PAB1 | Poly(A) binding | 4 RRMs | |
| PABPC4 | PAB1 | Poly(A) binding | 4 RRMs | |
| RNAP II large subunit | RPB1 | CTD | ||
| PP1 | PPP1CC | GLC7 | Phosphatase | PP2Ac |
| Rbbp6 | PACT | MpeI | DWNN, Zinc finger, RING | |
| Other yeast polyadenylation factors | ||||
| Unknown | HRP1 | RNA-binding | 2 RRMs | |
| Unknown | REF2 | RNA-binding | ||
| Unknown | SYC1 | CPSF73-100_C | ||
| Wdr82 | SWD2 | WD40 repeat | ||
| Ssu72 | SSU72 | CTD phosphatase | Ssu72 | |