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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2013 Nov 5;11(3):187–200. doi: 10.1038/nrgastro.2013.211

Figure 5. Hick-jacking of the autophagic system during liver viral infection.

Figure 5

Left: Hepatitis B (HBV) and C (HCV) virus induce formation of autophagosomes but prevent the degradation of these compartments by lysosomes. This allows virus to replicate inside or in the surface of autophagosomes. Right: Autophagy blockage has proven to be an effective anti-viral treatment against HBV and HCV by limiting viral replication and activating the host immune response.