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. Author manuscript; available in PMC: 2014 Apr 9.
Published in final edited form as: Br J Haematol. 2013 Feb 4;161(1):117–127. doi: 10.1111/bjh.12231

Figure 5. SINE compounds inhibit growth of MOLT-4 cells in vivo and provide a significant survival benefit.

Figure 5

(A) Mean bioluminescence of mice treated with vehicle, KPT-251, and KPT-330 during the 36 days of treatment or until mice became moribund and were sacrificed (n=8) All treatments significantly delayed leukaemia growth by two-way ANOVA analysis (p<0.0001). (B) Kaplan-Meier survival analysis of mice treated with vehicle control, KPT-251 and KPT-330 (n=8; p< 0.0001). (C) Weights of mice treated with vehicle, KPT-251, or KPT-330 from the start of treatment until day 21 are displayed.